When a fan is rated at 50cfm or 80 m3/h at 100% speed by how much is this figure decreased when taking into account the characteristics of the volume of the case?
Is it 20% or 80% for example?
The volume of the case will have nothing to do with the airflow. The resistance to airflow will and this will typically be determined by the minimum cross-sectional area of the airflow path.
What is the minimum cross-sectional area of the airflow path?
If it's not given you would have to work it out by measurement.
For a given airflow rate the volume of the case will determine the number of air changes per unit time.
What is the number of air changes per minute?
If the volume of the cabinet is, for example, 0.5 m3 and the airflow is 80 m3/h then the number of air changes per hour will be given by $ n = \frac f v = \frac {80}{0.5} = 160 $ (where f is the airflow and v is the volume. 160 changes per hour is almost 3 changes per minute.
Any filters or blockages will reduce the airflow.