you need to have your acrylic material properties data sheet, such as its modulus of elasticity, E and its max stress, $\sigma s$, and poisons ratio. Usually the acceptable deflection, y ranges between $y<L/180, \ or \ y<L/360$
Then you try different thicknesses, t, till you get the smallest t with acceptable deflection.
Referring to Roark’s Formulas
for Stress and Strain, by WARREN C. YOUNG
RICHARD G. BUDYNAS seventh edition table 11.4 pp 507
For a rectangular plate simply supported at the edges uniformly loaded with q:
$$y_{max}= \frac{-\alpha qb^4}{Et^3}$$
$$ \sigma max = \sigma b = \frac{\beta qb^2}{t^2}$$
The coefficients, $\alpha \ and \ \beta $ are shown in the following table.
