I am trying to build a SPR setup at home which is based off this diagram:

enter image description here

I wanted to try to miniaturize it and had some concerns about my strategy.

So I was thinking I could buy a big prism and maybe use a glass cutter tool from amazon to slice it cross-section wise to make it smaller. Although I am uncertain of this strategy or if there is a better method. As for the laser, I can find small lasers on amazon, but I was wondering which manufacturers could build me a laser smaller than the size of something like a finger nail or even smaller?

  • $\begingroup$ I was peripherally involved in feeding microscopic samples onto a commercial SPR device, where the client was manufacturing some kind of biomolecular assay. Can't speak for the optics but my impression was that even when working properly, which was not a given, it was extremely touchy and hypersensitive to disturbances. Seems hard for homebrew // just buy a prism (and all the optics) from Thorlabs or similar. // I think you would have to bond it to the surface coating too $\endgroup$
    – Pete W
    Jan 23, 2021 at 19:10


Your Answer

By clicking “Post Your Answer”, you agree to our terms of service and acknowledge you have read our privacy policy.

Browse other questions tagged or ask your own question.