Since you want to know what happens with a load applied to the corner of the desk, I'm going to simplify this question into two dimensions, assuming that the leg on that corner resists the load alone. Considering the fact that the rigidity of the steel members is orders of magnitude larger than that of the wooden desktop, this probably isn't too far from the truth.
I'm also going to assume that the desk is made of magical materials that don't have self-weight and that the desk is otherwise empty of other loads, just to keep things simple. Also, as others have mentioned, this is effectively impossible to do without some knowledge of statics. I can't give an entire lesson here, but I'm going to explain things as best I can.
The structure you effectively have is the following (removing the tail end of the desk after the foot, which is irrelevant, and the diagonal at the base of the foot, which just complicates matters and doesn't actually change the relevant internal stresses):

This particular case can actually be resolved by hand, so here goes:
The load at the very edge of the table is $300\text{lb}$ and is $12\text{in} = 1\text{ft}$ from the diagonal. That means that the beam has to withstand a bending moment of $M=300\cdot1=300\text{ft-lb}$ and a shear force equal to the applied load of $Q=-300\text{lb}$ (negative because it's pointing down).
Now we are at the point where the diagonal starts to help the horizontal beam, so we need to figure out how much force goes to each of them. For this, we have to look a bit ahead and notice that the horizontal beam meets the column at another pinned joint (those "balls" in the figure). These joints allow parts to rotate relative to each other, which (and this is something you learn in statics) means that the bending moment at that point is zero. Since there are no other external loads applied along those $20\text{in}$ (between the horizontal bar's connection with the diagonal and with the column), the shear force must be constant along that stretch. And since the shear force is the derivative of the bending moment, the moment must vary linearly. And since the diagonal is pinned ("ball" connection) to the horizontal, it didn't steal any of the moment. That means that the horizontal beam goes from a bending moment of 300 at the beginning of the diagonal to zero at the column. The constant shear force along that stretch is therefore equal to the tangent of that linear variation, which is
$$Q = \dfrac{300\text{ft-lb}}{20\text{in} = \frac{5}{3}ft} = 180\text{lb}$$.
So, going back to the connection between the horizontal and the diagonal, we now know that the horizontal beam went from a shear force of $-300\text{lb}$ to $+180\text{lb}$. That means that the diagonal must have applied a vertical force equal to $+480\text{lb}$ onto the horizontal. However, since the diagonal is pinned on both ends and has no external loads applied on it, it can only contain axial loads. That means that those $480\text{lb}$ are actually just a component of the force actually applied by the diagonal. The horizontal component can be easily found by the tangent and is equal to $480\cdot\frac{20}{5} = 1920\text{lb}$. The total axial force on the diagonal can be found by Pythogoras: $\sqrt{480^2+1920^2} = 1979\text{lb}$, and is of compression. Meanwhile, the horizontal component of this force has to be restrained by the horizontal beam, which therefore suffers a tension of $1920\text{lb}$.
All that's left now is the column. Since the horizontal beam is suffering a tension of $1920\text{lb}$, that needs to be absorbed by the column, which transforms that tension into a shear of $1920\text{lb}$. That shear, however, is cancelled out by the connection with the diagonal, which applies the same force (but onto a different side, therefore with a different sign... statics). Between those points, however, the shear is alive and well. And where there's shear, there's bending moment. A constant shear of $1920\text{lb}$ over $5\text{in}$ generates a bending moment of $1920\cdot\frac{5}{12}=800\text{ft-lb}$. Between the base of the column and the connection of the diagonal, there no longer is any shear, so the moment is constant.
Also, the horizontal beam had a shear of $+180\text{lb}$ which gets transmitted to the column as an axial tension of equal value (that part of the column is being stretched, not squished!). However, after the connection with the diagonal, which also dumps its horizontal component of $-480\text{lb}$ (it was positive at the top because it pointed up. Here it points down, so it is negative). Therefore, between the base and the diagonal, the column suffers a compression of $300\text{lb}$, which makes sense since that part of the column would have to withstand the entire external load which was applied at the edge of the table. If its compression weren't equal to that applied load, something would be wrong.
At the end of the day, you end up with a structure undergoing the following (click to expand):

However, knowing the internal forces is not sufficient to know whether your desk will support it. That, however, is highly dependent on where you live and which codes apply (and I'm sure desks don't have to follow structural codes, but I'm sure there's some relevant code) and can't adequately be answered here.
That being said, for tension and shear there's usually little mystery to it. For tension, divide the tensile force by the cross-section area and compare that stress to the steel's strength (the weakest A500 is 45ksi), with some safety factor (allowable stress design often uses 60% of the steel's strength). For shear, divide the shear force by the "shear area", which in your case is equal to the area of the "vertical" sides of the cross-sections. This gives you the shear stress, which should be compared to the steel's strength (allowable stress design uses 40% of the tensile strength).
Bending and compression, however, are more complicated due to the risk of buckling and need to be done by the relevant codes. If one ignores buckling (one really shouldn't), then it's just a matter of getting the relevant stress and comparing it to the strength again. For compression, that's the same as for tension. For bending, divide the bending moment by the elastic modulus to get the maximum tension/compression stress (see below) and compare against the allowable stress as well:
$$\sigma = \dfrac{6Mh_1}{b_1h_1^3-b_2h_2^3}$$
And, for what it's worth, the diagonal at the base of the foot might be relevant for buckling analysis, though if I had to guess I'd say the upper diagonal aiding the horizontal beam would be the controlling member (for buckling).